Orbital metastases

Orbital metastases: diagnosis and course | British Journal

Orbital metastases constitute 3% of all orbital diseases and 10% of orbital neoplasms in most series. Mean interval between diagnosis of primary tumor and the first orbital symptoms has been as long as 60 months. About 20% of metastatic tumors to the orbit were the first sign of cancer, and in 10%, the primary site could not be demonstrated. Orbital Metastasis Several types of cancer can spread (metastasize) to reach the tissues around the eye (orbit). The most common orbital metastases are cancers of the breast, lung, kidney or prostate gland. About 20% of patients who present with an orbital metastasis do not have a known primary cancer elsewhere Orbital metastases occur in 2% to 3% of patients with cancer. Metastases of breast cancer account for the majority of ocular and orbital metastases. Clinical signs and symptoms may include proptosis, diplopia, pain, exopthalmus, blurred vision and a visible or palpable tumor mass in the orbital or periorbital region In as many as 25% of choroidal metastases, multiple or bilateral tumours were present; bilaterality is much less frequent in orbital metastases. 4 5 20 25-27 In a series reported by Tijl and colleagues, four of 34 patients had bilateral orbital metastases and all of these bilateral cases had breast carcinomas. 2

Orbital metastasis, although uncommon, is a condition optometrists should consider in a patient presenting with proptosis, ptosis, diplopia, or a lid mass with a history of cancer. However, in as many as 19% of cases, patients have no prior or concurrent history of systemic cancer when presenting with ophthalmic symptoms Most orbital metastases are carcinomas; sarcomas and melanomas are considerably less common., Clinical presentations include diplopia (48%), proptosis (26%), pain (19%), decreased vision (16%), ptosis (10%), and palpable mass. Scirrhous breast carcinoma may present with enophthalmos

Orbital Metastases a) What are orbital metastases? Tumours starting elsewhere in the body can spread behind the eye in the orbit. This is rare, however, if a tumour is first found in the orbit then cancer elsewhere may have to be considered and looked for The orbit is an unusual site for metastatic cancer. Orbital metastases ranged from 1% to 13% among reported series of all orbital tumors-and from 2% to 5% among patients with systemic cancer. Several authors have reported their experience-,-, Muscle involved by metastasis usually presents with an area of segmental widening, irregular borders against the orbital fat, with/without bone changes ( Fig. 21.4 ). 40 Pain is a key symptom that helps differentiate metastasis from benign tumors and commonly is an indication of bone destruction and perineural involvement Orbital Metastasis Orbital metastasis may occur in children and adults and originate in a range of primary tumors

Metastatic Tumors of the Orbit - American Academy of

Objective: To inform clinicians of a metastatic orbital neoplasm that frequently masquerades as an orbital inflammatory syndrome and to stimulate thought regarding this neoplasm's fundamental pathobiology specific to its orbital involvement. Design: Interventional case report and literature review. Participants: A 47-year-old woman with an acquired, bilateral, diffusely infiltrative orbital. Images in Clinical Medicine from The New England Journal of Medicine — Orbital Metastasis in Breast Cance The most frequent metastases to the orbit are from breast, lung, prostate, melanoma, carcinoid, GI, renal cell, neuroblastoma, and rhabdomyosarcomas This case showed that retro-orbital metastasis should be considered as a differential diagnosis in a patient with thyroid cancer who presents with unilateral diplopia. [ncbi.nlm.nih.gov] Without 131 I therapy, diplopia occurred from metastasis to the right medial rectus muscle Orbital metastases represent an exceedingly rare metastatic manifestation of neuroendocrine tumors (NETs) and occur through hematogenous dissemination via the carotid and ophthalmic artery [].Orbital involvement, specifically from NETs of midgut primary origin, represents an even less common occurrence with our literature review identifying 20 such published cases [1,2,3,4,5,6]

Neurosurgery Residency: Orbital tumor

There is an increasing number of orbital metastasis, with an incidence of 1% to 13%. Of all cancers that affect the orbit, breast cancer is the primary source in 28.5% to 58.8% of cases. Other primary cancers that affect the orbit include non-small-cell lung, prostate, GI (esophageal), kidney, and skin (melanoma). Conversely, the orbit is an. of orbital metastasis are 25 and 28 years respectively.6,7 However, in up to 25% of cases, orbital metastasis is the initial finding of a previously undetected primary cancer.1,8-12 Due to a tissue-specific preference of breast cancer to extra-ocular muscle and surrounding orbital fat Orbital metastasis of urothelial carcinoma is very rare; only 22 cases have been documented. In this case report, we describe a patient 1 month status post transurethral resection of urothelial.

Orbital Metastasis Wills Eye Hospita

  1. Orbital metastases from neuroendocrine tumors are rare, accounting for no more than 5% of orbital metastatic disease, and usually arising from gastrointestinal primary tumors whereas uveal metastases are associated with a bronchopulmonary source ().Orbital disease may be the initial manifestation of the systemic disease or become evident up to 20 years after diagnosis of the primary tumor ()
  2. From the case: Orbital metastases: breast cancer. CT. Axial C+ arterial phase. Coronal C+ arterial phase. From the case: Orbital metastases: breast cancer. CT. Coronal C+ arterial phase. Sagittal C+ arterial phase. From the case: Orbital metastases: breast cancer
  3. orbital metastases (28.5-58.8% of all cases of orbital metastasis) followed by prostate and lung cancer [4]. Invasive lobular carcinoma (ILC) has a higher likelihood to metastasize in unusual sites such as the gastrointestinal tract, genitourinary system, peritoneum
  4. Orbital metastases are very uncommon in mesothelioma, with only a few reported cases. These usually occur in very advanced disease and affected patients have a poor prognosis. Radiotherapy is the mainstay of treatment, with tumour resection to alleviate physical symptoms and for emergent indications
  5. Orbital metastases from gastrointestinal malignancies rarely produce enophthalmos. Otherwise, bilateral orbital disease with enophthalmos in a woman is virtually pathognomonic for metastatic breast cancer, with a scirrhous fibrotic process accounting for ocular retraction

Orbital neuroblastoma metastases are commonly associated with poor prognosis. Among the 11 cases with orbital neuroblastoma metastases, systemic chemotherapy was initiated in 6 cases. Although the symptoms improved by follow up after 4 months to 2 years in 4 patients, 2 children died after chemotherapy Has Cancer Spread To Your Bones? Learn About A Preventive Treatment Optio ocular or orbital metastasis [19]. Still many breast cancer orbital metastases remain subclinical and are never diagnosed [20]. Infiltrating lobular breast cancer is a special breast cancer subtype. It accounts for 10-15% of all mammary carcinomas and for ~1% of all malignancies [21]. ILCs display a distinc mation, most of the orbital metastases were solitary. However, 5 patients had 2 metastatic foci in the affected orbit and 1 had 3 metastatic foci. In 15 (21%) patients there were ocular metastases in addition to the orbital metastases. These included 2 patients with metastases to the eyelid, 3 with metastases to the conjunctiva, and Orbital metastasis is relatively uncommon. In general patients with metastatic disease do not develop orbital metastases, being identified clinically in less than 1% of cases. Orbital symptoms occur well before local symptoms from the primary tumour manifest, and as such are the first indication of advanced malignancy [11,12]

Orbital metastases as first sign of metastatic spread in

Orbital metastases of NEN have a relatively low prevalence, more commonly associated with small bowel primary. Extraocular muscles are primarily affected, irrespectively of liver disease burden. Survival does not seem to be affected. EBRT is an efficacious treatment modality for both symptom relief and tumour growth control. Administration of. Intraocular metastases from midgut NET patients, spe-cifically to the uvea, may be more frequent than midgut NET orbital metastases [2]. The most common symptoms at presentation for pa-tients with metastatic orbital involvement include diplo-pia, proptosis, and decreased vision. Other common symptoms include eyelid swelling, chemosis and redness Abstract. Metastases to the orbit are found in the choroid, retrobulbar soft tissues, or bony orbit. Choroidal metastases result in retinal detachment and are best evaluated with fundoscopy and ultrasound. Retrobulbar metastases can involve both extraconal and intraconal spaces; they appear as masses having a high absorption value and irregular.

Background and Objectives Among orbital tumors, metastatic lesions have a prevalence of 1% to 13%; on the other hand, breast cancer is the most common malignancy causing orbital metastases. The aim. Orbital metastasis from colorectal cancer is extremely rare. In this case report, we describe a 48-year-old woman who presented with recurrent severe headaches and new onset constipation with no known history of cancer. After vigilant workup, imaging, and biopsies, she was diagnosed with orbital metastasis from a primary rectal carcinoma. She was started on chemotherapy and radiation therapy

Intraorbital metastases of solid tumors are a rarely diagnosed clinical condition, even though pathological reports suggest an incidence of up to 30% in cancer patients. We report two cases of intraorbital, extraocular metastases in breast cancer. The first patient was a 45-year-old man who presented with diplopia, upward divergence of the left bulb, and local pain Orbital metastases represent a rare condition and only 33 cases of metastases from hepatocellular carcinoma (HCC), usually revealed by slowly progressive exophthalmos, have been described in the literature. A 62-year-old man affected by HCC reported a sudden left exophthalmos and amaurosis. A cranial CT scan revealed pathological tissue occupying the superior portion of the orbit Orbital metastasis is reported in 18%-20% of cases. Proptosis and periorbital ecchymosis are the classic signs of metastatic neuroblastoma, whereas Horner syndrome and opsoclonus are infrequent findings as described by Ahmed et al. [4] Similarly, Yang et al. [5] reported a 3-year-old girl with proptosis, ecchymosis, and mass in the face as. Orbital metastases are relatively uncommon, the incidence ranging from 1 to 13% [1]. Breast cancer is the most common tumour that metastasizes to the orbit (48%-53% of orbital metastases) followed by prostate carcinoma, melanoma and lung cancer [2] Two months after radioiodine treatment, the CT showed a regression of the orbital tumor mass with concomitant decrease in thyroglobulin (428 ng/dL). Although orbital metastases of thyroid carcinoma are uncommon, thyroid carcinoma has to be considered as a potential primary tumor in a patient with an orbital metastasis

Neuroblastoma is predominantly a tumour of early childhood and between 10-20% of cases have orbital metastases. 2, 3, 4 Neuroblastoma originates in the adrenal medulla or the paraspinal sites. Orbital lesions, an exceedingly rare site of neuroendocrine tumor metastasis Journal of Cancer Metastasis and Treatment is an open access journal, focusing on basic and clinical studies related to cancer cell, cell biology, oncology, radiation therapy and radiology, obstetrics and gynecology, pediatrics, surgery, hematology, neuro-oncology, etc Abstract. • Prostate carcinoma was previously thought to be a rare source of orbital metastasis. We studied a clinical series of eight cases of orbital metastases from prostate carcinoma. Presenting symptoms included proptosis, pain, diplopia, eyelid swelling, decreased vision, ptosis, and red eye. The mean age at onset was 72.1 years

Pupillary size and equality - Genetic Testing - RR SchoolBone Tumors - Oncology - Mitch Medical Healthcare

Orbital metastases: diagnosis and course British Journal

Orbital metastases of lung cancer are rare. However, because the number of patients diagnosed with lung cancer is increasing, the probability that a physician will see a patient with an orbital metastasis is also increasing. Unfortunately, the clinical course and response of these patients to cytotoxic chemotherapy are generally poor and keeping a patient's quality of vision is difficult Orbital metastasis from anorectal carcinoma Journal of Cancer Metastasis and Treatment is an open access journal, focusing on basic and clinical studies related to cancer cell, cell biology, oncology, radiation therapy and radiology, obstetrics and gynecology, pediatrics, surgery, hematology, neuro-oncology, etc A diagnosis of an orbital metastasis from the carcinoma of the breast was made and an urgent CT scan showed a 2.5 × 2 cm 2 solid mass in the left orbit extending from the back of the globe to the. Orbital metastases account for a small proportion of orbital tumours. The incidence is reported between 1% and 13%. 1-3 Breast is the most common primary site ranging from 28.5% to 58.8%. Other common sites are lung, prostate, gastrointestinal system, kidney, and skin, respectively. 4-8 Vision loss and/or diplopia, red eye, pain.

Orbital Metastases - ScienceDirec

  1. Orbital exenteration and nodal metastasis are both associated with death due to disease, while a history of organ transplantation predicts orbital exenteration, according to research results published in Ophthalmic Plastic and Reconstructive Surgery.. Many previous reports on ocular surface squamous neoplasia or conjunctival squamous cell carcinoma focus on local treatments for bulbar.
  2. (2010). Orbital Metastases from Neuroendocrine Carcinoma, Masquerading as Graves Orbitopathy. Orbit: Vol. 29, No. 2, pp. 94-96
  3. Orbital metastasis as the initial presentation of lung adenocarcinoma: a case report. Abstract: Orbital metastasis as the initial presentation of lung adenocarcinoma is very rare, and so the lack of knowledge about this phenomenon can easily result in misdiagnosis, either as a orbital primary tumor or benign lesion
  4. Treatment for orbital metastases often requires a multidisciplinary approach and modalities include radiotherapy, chemotherapy, hormone therapy, surgery, and immunotherapy; however, the mainstay treatment is orbital irradiation because it can offer significant symptomatic improvement of orbital signs and symptoms [20, 40, 43]
  5. Orbital metastases occur in 2% to 3% of patients with can-cer. Metastases of breast cancer account for the majority of ocular and orbital metastases [1]. Clinical signs and symptoms may include proptosis, diplopia, pain, exopthal-mus, blurred vision and a visible or palpable tumor mas
Case Study: A Curious Case of Proptosis | USC Roski Eye

Orbital metastases: When to suspect? When to biopsy? Allen

Metastases to extraocular muscles belong to orbital metastases, the latter with an overall incidence ranging from 1 to 13% out of all metastatic cancers [].In 1990, Capone et al. made a thorough review of secondary malignancies from all over the body in this unusual site [].Our review is, on the other hand, the first up-to-date review on extraocular muscles metastases from breast cancer Abstract. Breast cancer is the main site of origin of orbital metastatic disease. Although invasive lobular breast carcinoma accounts for 10-15% of all breast cancer cases, it has been noticed that it metastasizes to the orbit more often compared to breast cancer of no special type (NST)

NHSGGC : Orbital Metastase

Orbital metastasis constitutes 3% of orbital lesions and 10% of orbital tumors. Breast cancer is the most common primary site for orbital metastasis in women with known disseminated disease and the ocular symptoms can appear years after the inicial brest cancer diagnosis . Considering all types of orbital metastasis, in 19%, there is no history. Orbital metastases represent a small but increasing percentage of all orbital tumours with an incidence of 1% to 13% in multiples studies and series. The primary site includes a variety of solid tumours but breast cancer is by far the most common one, followed by lung, prostate, gastrointestinal, kidney and skin (melanoma) cancers [1, 2, 3]

Orbital metastases in Ital

BackgroundOrbital metastases from cancers of various organs can arise via the hematogenous route, and many originate from breast, prostate, and lung cancers. Such metastatic orbital tumors may be diagnosed before the primary tumor. We have encountered a case of breast ductal carcinoma with neuroendocrine differentiation that metastasized to the orbit and responded to chemotherapy, with. The frequency of intra-orbital metastasis in systemic cancer is a controversial topic. Of all metastatic tumors to the orbit of the eye, breast carcinoma is considered to be the most prevalent Introduction. Orbital metastasis can be defined as a metastatic lesion that occurs in the space between the eyeball and bony orbital walls. 1 The orbit is an unusual site for metastatic cancer. It is believed to occur in approximately 2%-3% of patients with systemic cancer. 2,3 The incidence of orbital metastatic lesions varied from 1% to 13% of orbital tumors Orbital metastases were reported in nine patients with thyroid carcinomas (PTC=4, FTC=3, Hürthle cell=1, not specified=1). Patients with choroidal metastases presented with decreased or blurred vision, eye pain, and flashes in 81%, 5%, and 5% of cases, respectively. The diagnosis of a choroidal tumor was usually based on noninvasive diagnostic.

Metastatic and Secondary Orbital Tumors Ento Ke

Orbital metastases are very uncommon in mesothelioma, with only a few reported cases. These usually occur in very advanced disease and affected patients have a poor prognosis. Radiotherapy is the mainstay of treatment, with tumour resection to alleviate physical symptoms and for emergent indications. Contributor Orbital metastases tend to occur in the posterolateral orbital wall. Bone destruction may occur, specifically in the lateral orbital wall or sphenoid marrow. On Computed Tomography (CT), metastases can appear as either circumscribed or ill defined, are increased in attenuation compared to muscle, can contain small calcifications, and can invade. Introduction. Orbital metastatis as the initial presenting symptom from a metastatic lung lesion is a rare entity, occurring at an incidence of approximately 7% 1,2.However, this should be kept as one of the differentials in any patients presenting with orbital symptoms, so as to frame an accurate and effective plan of management About 2%-9% of all orbital neoplasms are metastatic lesions.(1) Breast, lung, lymphomas, and leukemia are among the most common primary neoplasms known to metastasize to the orbit.(2,3) The average age of onset of orbital metastasis from prostate carcinoma is later, compared to orbital metastasis from other malignancies (70.1 vs 53.6 years).(4,5 Orbital metastatic disease may result in proptosis or ecchymosis. Additionally, more than half of neuroblastoma patients have osseous metastatic disease at the time of diagnosis, which can manifest as Hutchinson syndrome if limping and irritability are present. 1. CT is the most common modality for radiographic assessment of neuroblastoma

Orbit Metastasis - an overview ScienceDirect Topic

The frequency of intra-orbital metastasis in systemic cancer is a controversial topic. Of all metastatic tumors to the orbit of the eye, breast carcinoma is considered to be the most prevalent. Orbital findings typically present themselves after the diagnosis of the primary tumor, with an average delay of three to six years. In spite of that, this study reports a case in which orbital. Critical diagnostic delay associated with unusual presentation of hepatocellular carcinoma (HCC) with orbital metastases: a case report. Daria M. Filippini, Alessandro Di Federico, Barbara Lenzi, Elisabetta Nobili, Stefano Brocchi, Deborah Malvi, Giovanni Brandi . Article Options The investigators also found that 52 of the patients had at diagnosis or developed orbital metastases, 31 of whom (59.6%) died. In addition, 37 of the 52 had or developed proptosis/ecchymosis and. Orbital metastasis is an infrequent cause of proptosis and is usually seen in patients harbouring advanced metastatic disease.1 2 For breast cancer, the time from diagnosing the primary disease to diagnosing the orbital metastasis varies from 4.5 to 6.5 years.1 3 In 25% of cases, orbital metastasis can be the initial finding for a previously.

Breast Carcinoma Metastatic to the Orbit - EyeWik

Orbital Metastases www.tcrt.org DOI: 10.7785/tcrt.2012.500257 Purpose of this study is to evaluate radiographic therapy response, clinical outcome and adverse effects of CyberKnife radiosurgery in patients suffering from orbital metastases. Sixteen orbital metastases originating from different solid cancers in fourteen patients wer Orbital and skin metastases in a polymorphous low grade adenocarcinoma of the salivary gland - Volume 109 Issue 1 Of these causes, congenital orbital asymmetry and trauma are the most common . Scirrhous metastatic breast cancer is the most common malignant condition that should be ruled-out in a female who presents with enophthalmos. In a review of 25 cases of orbital metastasis presenting with enophthalmos, 76% were caused by breast carcinoma Orbital metastasis of any systemic cancer is uncommon and there have been very few reports of orbital metastasis of RCC. Only two to five percent of patients with systemic cancer develop orbital metastasis and only 13% of all orbital tumors are metastatic . The most common primary tumors with orbital metastases are breast, lung, and prostate

Orbital metastatic osteosarcoma - PubMe

The 2021 edition of ICD-10-CM C69.6 became effective on October 1, 2020. This is the American ICD-10-CM version of C69.6 - other international versions of ICD-10 C69.6 may differ. Applicable To. Malignant neoplasm of connective tissue of orbit. Malignant neoplasm of extraocular muscle Orbital metastases are rare and have widely differing diagnoses, including lymphoma, carcinoma (most commonly breast or gas- trointestinal), melanoma, or other secondary orbital tumors. The unique feature of this metastatic lesion is its hypointense signal on both T1- and T2-weighted MR images. Only a single reported orbital metastasis from a small-bowel carcinoid tumor has been shown to have a similar appearance . Thus, when one deals with an intraorbital mass with the imaging appearance we have described, the differential. Pulmonary and liver metastases are common sites of distant metastasis from the rectal carcinoma. Metastases to the head and neck region are uncommon from carcinoma of the rectum, and orbital metastases are extremely rare. Here, we describe a 27-year-old female, who was diagnosed as a case of anorectal carcinoma in April 2010 Metastatic cancer can come from other parts of the body to form an orbital tumor. Lastly, an orbit tumor can also be caused by inflammation (e.g. pseudotumor, sarcoidosis) or infection (abscess). Lastly, an orbit tumor can also be caused by inflammation (e.g. pseudotumor, sarcoidosis) or infection (abscess)

ing orbital metastasis is poor as it occurs during the ad-vanced stage of the disease. The median survival is 7.4 months from the time of metastases (1). The principal treatment modalities are radiotherapy, hormonal therapy, chemotherapy, and surgery. Radiotherapy is the mainsta Orbital metastasis as initial presentation of adenocarcinoma of lung is an extremely rare phenomenon. Here, we report a 46-year-old non-smoker Asian woman, who presented with right eye proptosis due to right orbital and infratemporal fossa metastasis, as the first presentation of adenocarcinoma of right lung Orbital metastasis is a significant cause of orbital disease in adults and accounts for 3-10% of all orbital tumors. While embryonal tumors, neuroblastomas, Ewing's sarcomas and Wilms tumors are responsible for most pediatric metastatic orbital tumors, orbital metastases in the adult population are predominantly from breast, lung, and.